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Otus was one of the Argonauts who sailed with Jason to bring the Golden Fleece to Argos. Ten years later, he reunited with the Argonauts on a second expedition of the Argo when Castor and the Blood-Eye Cult stole the Fleece. Otus did not get along well with Artemus. Otus was loyal to Jason without a fault and Artemus disagreed. Otus was killed aboard the Argo during the second expedition by Castor, presumably because of his undying loyalty to Jason.